; al. Oelbaum;
Sinuous tree trunk, leaves opposite, persistent, whole and coriaceous. Flowers actinomorphic with perianth tetramer and ovoid fruit drupa in bone - hard monoseminado, which contains mesocarp (when ripe) 50% lipids.
tree, for some "symbol fitoclimáticas
eumediterráneas of" unknown status in
. It is believed that began grown in Syria, Palestine: plants that have spontaneously returned to their state have given rise to different taxa, particularly the oleastro.
leaf contains minerals (
) neutral lipids, and
glucolípidos, triterpenes (oleanólico acid and its derivative 2 -
hydroxylated) flavonoids (rutoside, monkey gods and flavones) The presence of alkaloids
yet to be confirmed.
of the drug is related to the heterósidos of Genina heterocyclic: the secoiridoides. These, and in particular the secologanósido - its precursor, just keep the cycle pyran kernel cyclopentapyran iridoides the strict sense. The compound oleuropeósido - Main - group is the diester in methanol (11) and 3, 4 - dihydroxy Phenethyl (7) of oleósido, glucoside secoiridoide dicarboxylic. Appears accompanied by dimethyl - oleuropeósido, dimethyl ester oleósido and ligstrósido (4 - hydroxy ester - Phenethyl) Have been isolated from aldehyde not heterosídicos. It
published the structure of oleurósido, ester dihydroxy - 3, 4 Phenethyl of dry - logan 
The hypotensive action of
or leaves decoctions based on
were first confirmed in humans and later in dog and rat. In 1972, Petkov et al. showed that the oleuropeósido, administered iv the dog
significant and prolonged decline in blood pressure. Both this compound as an extract of leaves, administered orally, in normotensive and hypertensive rats, are involved antihipertensora and
. On the other hand, the oleuropeósido increases
flow and left intraventricular pressure on the isolated rabbit heart.
The oleuropeósido is also spasmolytic:
of rats, the oleuropeósido antagonized in
non - competitive action contracturante cumulative dose of acetylcholine in the fundus of the
of rats. It is
receptor antagonist of PGE2.
Other activities have been identified as yet unproven scientifically: action on blood glucose, hyperthermia, urine output. Recently, it
attributed antiulcer properties related to the presence of acid oleanólico. This, and its salts are orally active.
Observations on the Man.
Most of the comments in the press are old:
they may include those of Mazet (1938) who asserts that the long - term treatment with
decoction of leaves, previously stabilized, leading to
normalization of blood pressure. Other studiescome to similar conclusions.
shown that the drug spray adimistrada
dose of 1 or 2 g / day lowers
significantly, from 15 - day variation with
favorable lipoprotein (LDL
reduction and increased HDL)
former study, very partial, mentions the absence of acute toxicity of total extract of the leaves of
administered to guinea pig. Recent work
also demonstrated the safety of the oleuropeósido. Its traditional use as febrífugo
been abandoned by the phytotherapeutic, those who defend the properties hypotensive confirmed in animal treatment of
, prevention of
. The forms are used infusion, the extract of leaves of nebulized stabilized, dust sheets criomolido. There have been no cases of contraindications. Tests have shown the drug spray the absence of acute and subacute toxicity in rat.
In Spain authorizing the use of this plant for mild
. Adjunct in the treatment of
Leaf is simple, subsessile, lanceolate (3 - 5 x 1 - 1. 5 cm) hard edges are rolled on drying. The top surface of the blade is gray green, the bottom is covered with fine hairs that flow easily with the friction and give it
soft, whitish appearance. Observed under
microscope, the two are very cutinizadas epidermis: the lower epidermis is covered with trichomes Pelto with cells, arranged radially around
foot. The test includes physical - chemical characterization of acid oleanólico in an ether extract and an analysis by CCF maceration ethanolic
been developed by analyzing high - performance
chromatography of oleuropeósido and other compoundspresent in the fruit.
Encyclopaedia Universalis, Paris, 9, 1019 - 1021, 1979.
B. Harborne and
. S. GREEN.
chemotaxonomic survey of flavonoids in leaves of the Oleaceae.
Bot. J. of the Linnean Soc. 81, 155 - 167, 1980.
. Gariboldi, G. JOMMI and L. VEROTTA.
Secoiridoids from Olea europaea.
Phytochemistry, 25, 865 - 869, 1986.
. INOUE INOUE.
secoiridoid GLUCOSIDE from Olea europaea.
Phytochemistry, 27, 1757 - 1759, 1988.
G. COMBES and
Nouveau comes from preparing an extract of feuilles d'Olea europaea rich Oleuropein, products obtained, by way of Application médicaments et les compositions renfermant.
Brevet d'invention français No 81 - 11 606; 12 - 06 - 1981) G. COMBES and
B. Lasserre, R. KAISER,
. Chanh, N. IFANSIYAH, J. Gley and
Effects on rats of aqueous extracts of plants used in folk medicine as antihypertensive agents.
Naturwissenschaften, 70, 95 - 96, 1983.
. RIBEIRO, M. M. R. FIUZA DE MELO,
. DE BARROS,
. GOMES and G. TROLIN.
Conscious Acute antihypertensive effect in rats produced by some medicinal plants used in the state of Sao Paulo.
J. of Ethnopharmacology, 15, 261 - 269, 1986.
Brevet d'invention européen No 93 250, 1983 cited by
. MEUNIER, La feuille d'olivier, Olea europaea L, Thèse of Doctorat in Pharmacie, Diplôme d'Etat) Paris IX, 1986.
L'Olivier, Olea europaea L. Oléacées) Medicinal plants d'actualité.
Act. Pharm. 215) 27 - 30, 1984.
Contribution à l'étude de l'action of the antihypertensive feuille d'olivier: l'Oleuropein, Prince antihypertenseur assets. Thèse de l'Universite de Montpellier, Mention Pharmacie) Montpellier, 1983.
Pharmacopée française, X ed.
V. PETKOV and
Pharmacological analysis of the
Arzneim. Forsch. 22, 1476 - 1486, 1972.
M. J. AMIOT,
. FLEURIET and J. J. MACHEIX.
Importance and evolution of Phenolic compounds in
during growth and maturing.
J. Agric. Food Chem. 34, 823 - 826, 1986.
Phytochimiques Recherches sur les principes et pharmacologiques active in plants used as traditional medicine in antihypertenseurs. Doctoral Thesis of the third cycle ès Sciences pharmaceutiques, Toulouse, 1982.
Olivier, toxicologique dossier, Travaux des Laboratoires
whose treatment is appropriate in this plant.
Moderate essential hypertension