autumn crocus
autumn crocus
Used Part.
The seeds, bulbs occasionally.
Active Principles.
Seeds:
isoquinoleínicos alkaloids (0, 30 - 1, 2%) mainly colchicine, democolchicina and colchicósido. Tannins.
Essential
oil.
Bulb:
alkaloids (0. 3 - 0. 6%)
organic
acids, apigenósido.
Drug Action.
The alkaloids confer an analgesic, anti - inflammatory and diuretic.
Indications.
Crisis of gout.
Contraindications.
Pregnancy
, infancy. Or renal impairment.
Side Effects.
In internal use can cause
gastroenteritis
.
Caution / Poisoning.
The treatment of acute gout requires close medical surveillance.
Alkaloids, especially colchicine, are very toxic, behaving as emetocatárticos can produce, in case of poisoning, death from
respiratory
collapse or leave serious sequelae: leukopenia and
depression
of immunity.
Accidental poisonings are generally rare,
but
with high mortality rates (30%) in the absence of
a
specific
antidote.
Galenica forms / Dosage.
See section of precautions.
Fluid extract (0. 35% of colchicine) 1 - 3 drops, 2 - 3 times
a
day.
Colchicine amorphous USP:
In acute gout are administered 3 mg the first day, 2 mg the second and then 1 mg / day.
Bibliography.
Benigni, R; Capra,
C
; Cattorini,
P
. Piante Medicinali. Chimica, Pharmacology and Therapy. Milano: Inverni & Della Beffa, 1962, pp. 342 - 70.
Bézanger - Beauquesne, L; Pinkas, M; Torck, M. Dans la Plantes Les Thérapeutiques Moderne. 2. Paris: Maloine, 1986, pp. 164 - 5.
Bézanger - Beauquesne, L; Pinkas, M; Torck, M; Trotin,
F
. Medicinal plants of temperate Regions. Paris: Maloine, 1980, pp. 53 - 4.
Bruneton, J. Elements of Phytochemistry and Pharmacognosy. Zaragoza: Acribia, 1991,
p
. 453 - 7.
James,
A
; Duke, Ph.
D
. Handbook of Medicinal Herbs. 5. Boca Raton,
Florida
: CRC Press, 1987, pp. 136 - 7.
Fernandez, M; Nieto,
A
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p
. 64.
Lastra, JJ; Bachiller, LI. Medicinal Plants in Asturias, Cantabria and the cornice. Gijón: Ediciones Trea, 1997, pp. 116 - 7.
Paris, RR; Moyse, M. Summary of Matter Médicale. Take II. Paris: Masson, 1967, pp. 30 - 35.
Peris, JB; Stübing, G; Vanaclocha, B. Applied
Fitoterapia
. Valencia: M. I. Official College of Pharmacists, 1995, pp. 225 - 6.
Samuelsson, G. Drugs of
Natural
Origin
.
A
Textbook of Pharmacognosy. Stockholm:
Swedish
Pharmaceutical Press, 1992, pp. 203; 241; 244.
Simon, R. Guide for Pharmaceutical and Medical Pharmacology. Madrid:
A
Madrid Vicente, 1993, pp. 83; 224.
Trease, GE, Evans, WCh. Pharmacognosy.
Mexico
City: Inter - MacGraw - Hill, 1991, pp. 651 - 5.
Van Hellemont, J. Compendium of Phytothérapie. Bruxelles: Association Pharmaceutique Belge, 1986, pp. 110 - 1.
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