PIGEUM
PIGEUM
Used Part.
The bark.
Active Principles.
Complex lipid - sterolic:
n - tetracosanol, n - docosanol (aliphatic
alcohol
) and its esters. beta - sitosterol. Flavonoids.
Organic
acids.
Drug Action.
Clinical studies show that the complex lipid - sterolic reduces voiding
disorders
associated with
benign
prostate
adenoma (pollakiuria,
urinary
urgency and nocturia) increasing urine flow and reducing the volume of residual urine, which is accompanied by
a
sense of improvement symptomatic and
a
subjective
feeling
of improvement in the quality of life. Does not reduce the size of the adenoma.
Some clinical studies show that its effectiveness is comparable to that of
Serenoa
repens
.
Its mechanism of action
has
not been fully elucidated. Several factors can influence, especially its anti - inflammatory action (by inhibition of 5 - lipoxygenase of polymorphonuclear to infiltrate the
prostate
tissue) and its effect regenerative epithelial secretory
prostate
, which helps to reset the
function
of secreting gland (to be
has
described the complex lipid - sterolic of Prunus africana induce
prostatic
epithelial regeneration in animals)
Although most studies exclude its interaction with the metabolism of testosterone, which
has
been described, in vitro, in part inhibits 5 - alpha - reductase and aromatase, so it should not be ruled out possible action on the
prostate
epithelium, Whose growth is hormonodependiente.
Recently it
has
been found that the extract inhibits in vitro, cell proliferation and induced the main factors of
prostate
tissue growth (EGF, epidermal growth factor, bFGF, growth factor and basic fibroblast of IGF - 1 (
Insulin
- like Growth Factor 1) Inhibition of proliferation
was
also observed in the absence of stimulation and with cells stimulated by an activator of
protein
kinase
C
(TPA)
Some animal studies show that the complex lipid - sterolic of Prunus africana, in high doses, prevents the functional
problems
of her
bladder
caused by partial blockage of the urethra,
bladder
without reducing the compensatory
hypertrophy
.
Indications.
Benign
prostate
adenoma, pretreatment
prostate
surgery,
urinary
disorders
post - adenomectomy.
Prostatitis
.
Some reviews suggest that clinical studies have been too limited duration and that there
has
been
a
lot of variability in their design, so that the evidence of the clinical usefulness of Prunus africana require longer studies, with standardized preparations.
Side Effects.
It can produce slight gastric discomfort.
Galenica forms / Dosage.
Excerpt lipid - sterolic:
100 mg / day in two doses.
It should prescribe long - term care (at least 60 days) It's very interesting to their association with
echinacea
,
nettle
and the palm of
Florida
(Peris et al. 1995; Mc Caleb)
Bibliography.
Bézanger - Beauquesne, L; Pinkas, M; Torck, M. Dans la Plantes Les Thérapeutiques Moderne. 2. Paris: Maloine, 1986, pp. 354 - 5.
Bruneton, J. Elements of Phytochemistry and Pharmacognosy. Zaragoza: Acribia, 1991,
p
. 84.
MacCaleb, R. Synergistic action of Pygeum and
Nettle
Root extracts in
prostate
disease
. Herbalgram, 1997; 40: 16.
Peris, JB; Stübing, G; Vanaclocha, B. Applied
Fitoterapia
. Valencia: M. I. Official College of Pharmacists, 1995, pp. 414 - 5.
Indications.
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