RYE ergot
claviceps purpurea
RYE ergot
claviceps purpurea
Used Part.
The sclerotia.
Active Principles.
Amines:
tyramine, histamine.
Alkaloids lysergic acid derivatives, of two types:
Water:
ergometrine or ergobasina, ergometrinina or ergobasinina.
No water:
Group of ergotamine (ergotamine, ergosina and its isomers)
Group of dihidroergotoxina (ergocristina, ergocriptina, ergocornina and their isomers)
Drug Action.
The alkaloids of the group of dihidroergotoxina produce an effect on blocking alpha receptors: vasodilation
central
,
peripheral
vasoconstriction (in low doses) relaxation of the cervix, decreased blood pressure.
Indications.
Bleeding
due to fibroids,
postpartum
polyps
. Hemicránea, paroxysmal tachycardia,
cerebral
circulatory
failure
.
Contraindications.
Pregnancy
hypertension
. Incompatible with vasoconstriction and with macrolide antibiotics, and that enhance
peripheral
vasoconstriction (Peris et al. 1995)
MAOI antidepressant treatment with the tyramine interacts may trigger hypertensive crisis (Farnworsth: 34)
Caution / Poisoning.
It is
a
very active plant: incorrect dosages, differences in the content of alkaloids, individual sensitivity to the drug administrations or long, can determine vomiting,
cramps
, spasms, delusions and even death.
Galenica forms / Dosage.
We recommend the use of alkaloids and their associations in the form of pharmaceutical standard, which facilitates the strength and reduces the possibility of poisoning.
Bibliography.
Benigni, R; Capra,
C
; Cattorini,
P
. Piante Medicinali. Chimica, Pharmacology and Therapy. Milano: Inverni & Della Beffa, 1962, pp. 1454 - 501.
Bézanger - Beauquesne, L; Pinkas, M; Torck, M. Dans la Plantes Les Thérapeutiques Moderne. 2. Paris: Maloine, 1986, pp. 154 - 7.
Bézanger - Beauquesne, L; Pinkas, M; Torck, M; Trotin,
F
. Medicinal plants of temperate Regions. Paris: Maloine, 1980, pp. 9 - 10.
Bruneton, J. Elements of Phytochemistry and Pharmacognosy. Zaragoza: Acribia, 1991, pp. 474 - 88.
Farnworsth, NR. Relative safety of
herbal
remedies
.
Natura
Medicatrix, 1995; 37 - 78: 30 - 35.
Fernandez, M; Nieto,
A
. Medicinal Plants. Pamplona: Ediciones Universidad de Navarra, 1982,
p
. 62.
Mulet, L. Ethnobotanical survey of the province of Castellon. Castellon: Provincial, 1991,
p
. 125.
Paris, RR; Moyse, M. Summary of Matter Médicale. Take I. Paris: Masson, 1986, pp. 328 - 40.
Peris, JB; Stübing, G; Vanaclocha, B. Applied
Fitoterapia
. Valencia: M. I. Official College of Pharmacists, 1995, pp. 239 - 40.
Simon, R. Guide for Pharmaceutical and Medical Pharmacology. Madrid:
A
Madrid Vicente, 1993, pp. 13, 101.
Samuelsson, G. Drugs of
Natural
Origin
.
A
Textbook of Pharmacognosy. Stockholm:
Swedish
Pharmaceutical Press, 1992, pp. 274, 278; 280.
Trease, GE, Evans, WCh. Pharmacognosy.
Mexico
City: Inter - MacGraw - Hill, 1991, pp. 657 - 64.
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