LOVELIA
lobelia inflata
LOVELIA
lobelia inflata
Used Part.
The leaves.
Active Principles.
Have been isolated
a
score of alkaloids of the type of piperidine and methylpiperidine, the most important of which is lobeline. They also highlight the lobelanina and lobelanidina.
Drug Action.
Pollen is
a
adrenergic (sympathomimetic) increases the frequency and strength of the
heartbeat
, serving as coronariodilatadora, decreases peristalsis and increases
intestinal
tone. Causes
release
of
liver
glycogen, inhibit bile secretion, decreased urine output, is vasoconstrictor, it increases blood pressure. By unloading produce adrenaline, stimulates the
central
nervous
system
- level centers bulbares, producing bronchodilation. The isolobinina
has
a
balmy, expectorant and antiasmático.
Indications.
Asthma
,
chronic bronchitis
,
emphysema
,
respiratory
failure
(such as emergency medication) For his gangliopléjico effect similar to nicotine (it acts as an antagonist) advocated their use in nicotine
addiction
.
Contraindications.
Hypertension
,
pregnancy
, lactation. Do not prescribe psychiatric drugs simultaneously or with other drugs alkaloids.
Caution / Poisoning.
It is
a
very toxic plant (DL = 4g) can cause vomiting,
diarrhea
, hypotension, tachycardia, and bradycardia, followed by anxiety, stupor, convulsions and death from
respiratory
paralysis.
Due to differences in the composition of the plant depending on its provenance, it is more advisable to use standardized forms, valued at lobeline, or alkaloids isolated or semisynthetic.
Galenica forms / Dosage.
Tincture (1:
10) 100 - 300 mg, one to three times
a
day. Maximum dose = 3 g / day.
Dust micronized:
50 to 300 grams, one to three times
a
day. Maximum dose = 1. 5 g / day.
Bibliography.
Benigni, R; Capra,
C
; Cattorini,
P
. Piante Medicinali. Chimica, Pharmacology and Therapy. Milano: Inverni & Della Beffa, 1962, pp. 867 - 80.
Bézanger - Beauquesne, L; Pinkas, M; Torck, M. Dans la Plantes Les Thérapeutiques Moderne. 2. Paris: Maloine, 1986, pp. 274 - 5.
Bézanger - Beauquesne, L; Pinkas, M; Torck, M; Trotin,
F
. Medicinal plants of temperate Regions. Paris: Maloine, 1980,
p
. 350.
British
Herbal
Pharmacopoeia. Vol. I. Bournemouth, Dorset: British
Herbal
Medical Association, 1990,
p
. 63.
Bruneton, J. Elements of Phytochemistry and Pharmacognosy. Zaragoza: Acribia, 1991, pp. 398 - 401.
D'Arcy, PF. Adverse reactions and interactions with
herbal
medicines. Part II. Drug interactions. Adverse Drug React Toxicol Rev 1993; 12 (3) 147 - 162.
James,
A
; Duke, Ph.
D
. Handbook of Medicinal Herbs. 5. Boca Raton,
Florida
: CRC Press, 1987, pp. 280 - 1; 520; 559.
Paris, RR; Moyse, M. Summary of Matter Médicale. Take III. Paris: Masson, 1971, pp. 301 - 6.
Peris, JB; Stübing, G; Vanaclocha, B. Applied
Fitoterapia
. Valencia: M. I. Official College of Pharmacists, 1995, pp. 350 - 1.
Samuelsson, G. Drugs of
Natural
Origin
.
A
Textbook of Pharmacognosy. Stockholm:
Swedish
Pharmaceutical Press, 1992,
p
. 247.
Simon, R. Guide for Pharmaceutical and Medical Pharmacology. Madrid:
A
Madrid Vicente, 1993,
p
. 59.
Trease, GE, Evans, WCh. Pharmacognosy.
Mexico
City: Inter - MacGraw - Hill, 1991, pp. 623 - 5.
Van Hellemont, J. Compendium of Phytothérapie. Bruxelles: Association Pharmaceutique Belge, 1986, pp. 237 - 8.
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