CYPRESS
CYPRESS
Cypress
; al. Immergrüne Zypresse;
English
.
Cypress
.
Gálbulos.
This tree monoecious reddish gray bark is characterized by its small triangular leaves, and opposing Entrecruzadas closely intertwined in four rows in the group: young leaves are aciculares at first, quickly becoming "cupresiformes. ".
Source
.
A
native of the regions border the Aegean Sea, lies across the Mediterranean. In the dry soils, deep in southern Europe are widely grown varieties (sempervirens way, shape. horizontalis) and species nearby ornamental purposes.
Chemical composition.
Still do not know the exact composition of the various organs of the
cypress
. Like all species of the genus,
C
. sempervirens is characterized by the presence of bis - flavonoids in their branches: biflavonas 8 - 8 ' (type cupresuflavona) and 8 - 3' (type amentoflavona) Also, the branches provide
a
small amount of
essential
oil (0, 3 - 0, 8%) rich in hydrocarbon monoterpenes (pinene, carene, canfeno, etc. Sesquiterpenes and diterpénicos (sandaracopimaradieno, abietadieno, abietatrieno) with derivatives oxygenates (cedrol) The gálbulos of
cypress
contain acids diterpénicosand proantocianidoles [234] to those who owe their biological
activity
: dimers and oligomers of catechol and epicatecol.
Pharmacological data.
There are few jobs that are specifically dedicated to gálbulos of
cypress
. It
has
been shown that fractions enriched in flavanólicos oligomers inhibit the activities trípsica and
a
- quimotrípsica in vitro. On
a
synthetic substrate, these fractions inhibited (
a
concentration of 0. 05 mg / ml) 50% of the
activity
of pig
pancreatic
elastase, this inhibition could help protect the connective tissue of the effects of enzymes involved in their degradation. The study of the spread of
a
coloring atóxicoen rat angioprotector demonstrates the power of 50 mg / kg of oligomers flavanólicos. More recently, it
has
been shown to proantocianidoles are good in vitro inhibitors of angiotensin converting enzyme I and which, in vivo, his administration carries
a
prolonged decline in vasoconstriction in the presence of this enzyme (rabbit, 5 mg / kg, iv) 237] On the other hand, it
has
been demonstrated with proantocianidólicos compound of the same type that these compounds stabilized by collagen formation of links with it.
Observations on the Man.
The effectiveness of
cypress
in the treatment of venous
diseases
has
been amply confirmed. It shows
a
significant asset in the functional
disorders
of the
circulatory
failure
of the lower limbs.
A
randomized study with
cypress
spray versus diosmine (flevotónico reference) clearly demonstrates the interest and the superiority of the drug plant. The criteria considered are: heaviness in the legs, pains,
cramps
and edema after 2 months of treatment with
cypress
spray, saw
a
80% success compared to 53% obtained with the reference product.
Employment.
Traditionally, the
cypress
is used in the treatment of the signs of venous insufficiency and hemorrhoidal symptoms. With this indication, is part of many specialties. The drug seems devoid of toxicity.
A
toxicological study shows that the total dust did not cause any toxic manifestation in the animal: acute toxicity (2. 5 g / kg) and subacute (500 and 1000 mg / kg / day)
The drug.
The successful cones, called "gálbulos" are rounded and are found singly or in groups of two. They are formed from scales, fleshy and mucronata at its center, which lignified to acquire
a
yellowish gray. When the scales
mature
, releasing their seeds. You can perform an analysis of the drug by CCF
a
tincture (with disclosing antimony trichloride aldehyde and
anise
)
Bibliography.
S. NATARAJAN, V. V. S. Murti and
T
. R. Seshadri.
Biflavones of some plants Cupressaceae.
Phytochemistry, 9, 575 - 579, 1970.
J. Garnered,
P
. Buil,
D
. JOULAIN and R. Tabacchi.
Contribution to the study of the chemical composition of the
essential
oils of rameaux Cyprès of Grasse.
Rivista Italiana
E
.
P
.
P
. O. S. 60, 99 - 117, 1978.
R. M. CARMEN M.
D
. SUTHERLAND.
Cupressene and other diterpenes of Cupressus species.
Aust. J. Chem. 32, 1131 - 1142, 1979.
P
. BERNARD,
P
. SUSPLUGAS, G. BALANSARD and M. LALLEMAND.
Séparation rapide des diterpéniques acid contents in the galbules of Cyprès, Cupressus sempervirens L. au moyen of the liquidated Chromatographia préparative (Chromatospac prep. Jobin Yvon 100)
Plantes Méd. Phytother. 12, 137 - 143, 1978.
P
. Delaveau Cyprès,
Cupressus sempervirens L. Cupressacées)
Act. Pharm. 230) 65 - 66, 1986.
M. JONADET, M.
T
. MEUNIER,
F
. VILLIE, J. BASTIDE and
P
. BASTIDE.
Catéchines et des oligomers flavanoliques Cupressus sempervirens, Inhibition et des activités trypsique
a
- chymotripsique in vitro and in vivo compared angiopretectrices activities.
J. Pharmacol. 15, 546 - 547, 1984.
J. JONADET, M.
T
. MEUNIER,
F
. VILLIE, J. BASTIDE and
P
. BASTIDE.
Catéchines et oligomers flavanoliques Cupressus sempervirens L. Inhibitrices activities vis - à - vis de l'elastase in vitro and in vivo activities angioprotectrices buy.
Ann. Pharm. Fr. 42, 161 - 167, 1984.
M.
T
. MEUNIER,
F
. VILLIE, M. JONADET, J. BASTIDE and
P
. BASTIDE.
Inhibition of angiotensin I converting enzyme by flavanolic compounds: in vitro and in vivo studies.
Planta Med
. 53, 12 - 15, 1987.
Étude clinique randomisée powder totale contre Cyprès of Diosmin (unpublished) Documentation scientifique des Laboratoires
Arkopharma
.
Cyprès, toxicologique dossier. Travaux des Laboratoires
Arkopharma
.
Diseases
whose treatment is appropriate in this plant.
Iinsuficiencia
venous.
Varices
.
Hemorrhoids
.
Menopause
.
Dysmenorrhea
.
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