NONI

morinda citrofolia

NONI
morinda citrofolia

Other Names:

Tahiti and Raratonga: Nonu, Nono.

Malaysia: Mengkudo.

Southeast Asia: Nhau.

India: Indian Mulberry.

Caribbean: Bush, Tree of Painkiller.

Australia: Cheesefruit, Fruit Polynesian.

Fiji: Kura.

Africa: Bumbo.

Vietnam: Morinda magnificent.

It is a shrub or a bush imperishable and can come in the middle stage of fifteen to twenty feet.

The fruit looks like a grenade green and covered with reddish brown holes of the seed that give a lumpy texture.

The noni fruit starts green, yellow loops, white and matures to the falls from the tree.

The tree bears fruit all year round. Once you choose a fruit, a new take its place after only three months!

The fruit of noni in its raw form is. bad smell and taste.

Originated in India, now growing in various parts of the world such as French Polynesia and Central America (it is known that the best is from Panama and the Pacific islands as Tahiti, Hawaii, South East Asia)

It grows best in rich volcanic ash. enmineral.

The earliest reference to noni which is used as a medicine dates back several thousand years of Sanskrit scriptures of India when it was used in Ayurvedic medicine.

Noni is used in medical systems natives of the Pacific islands of the southern and central, including Tahiti, Samoa, Tonga and Hawaii, Southeast Asia for example Malaysia and the Philippines. Although knowledge is more extensive, is the French who really did polynesians noni to the part of their cultural life.

Noni was, and remains, prescribed by the curators Polynesian native to treat pain, inflammation, burns, skin problems, intestinal worms, nausea, pasta, fevers, bowel and menstrual problems, bites and so on. insect and animal.

The parts used include the bark, leaves, flowers, fruit and seeds.

Noni was introduced to the Western world in the early twentieth century.

According to Dr. Neil Solomon, who is considered a recognized leader in nutrition and naturalists, noni has been reported to be safe for pregnant and / or mothers in the office of nurse. Noni can also be taken with all other medications and food supplements.

It is not addictive.

Tahitian Noni Juice ™ has been included in the 2003 edition of the reference desk of doctors.

Nutraceuticals.

NUTRACEUTICALS over 150 have been found in the noni fruit, some of those identified are: anthraquinone, beta - carotene, calcium, LINOLEIC acid, magnesium, pectin, potassium, proline, protein, proxeronine, proxeroninease, scopoletin, beta - sitosterols, sterols, And PHENYLALANINE TYROSINE, ursolic acid, all of vitamins and antioxidants like vitamin B.

C, proanthocyanadins and anthocyanadins.

How Noni works? and why it might be good for so many conditions)

Our work of the bodies by biochemical reactions. Examples include the growing hair, digesting food, healing injuries, fighting infections, walking, thinking, feeling and so on.

There are certain processes in our bodies that are primary and supportive of the whole body. Any change in these primary processes can cause dramatic changes through our whole body and other aspects of our lives.

Two of the major primary processes include the processes of synthesis and communication.

The summary includes all the things our bodies do, for example, proteins, connective tissues, cells, hormones, DNA and so on.

The communication refers to the flow of information between cells chemically controlled, coordinated suitable for the growth of the human body as a whole.

Globular proteins are WorkHorse processes for the synthesis (enzymes) and communication (recipients of the cell wall)

Globular proteins are long strands of amino acids connected as grain in a sequence. Big and Wobbly, spend only a very short time in the exact form that does most of his work schedule.

More on protein.

The enzymes catalyze each biochemical reaction in the body and recipients of the cell wall are responsible for much of the biochemical communication that happens in the body.

To increase the effectiveness of an enzyme or a receptor, our bodies produce a small molecule called the xeronine.

that was coined between the filaments of the protein, making it more rigid and therefore more time in their past.

biochemist efficient configuration.

Dr. Ralph Heinicke, a biochemist from the investigation, initiated the study of alkaloid Xeronine. Xeronine occurs in the body large intestine.

Our bodies contain all these blocks but proxeronine may dwindle.

Under usual circumstances, the liver stores proxeronine, thus freeing the blood every two hours.

The additional amount of required proxeronine comes from the food we eat.

But the depletion of soil & environmental degradation has reduced the number of components xeronine in our food.

Also diseases, aging, stress, etc. highly active lifestyle has placed an increased demand in the proteins in our body.

To increase the supply of xeronine in our body, more proxeronine need to be supplied by our diet.

Noni is found to contain, in abundant quantity, the building blocks for xeronine, namely proxeronine & enzymes needed to convert proxeronine in xeronine, known as proxeronase.

One of the first scientists to investigate the noni was Dr. Ralph Heinicke.

5 Uses main Noni:

1. Tonic daily - can be taken together with other supplements, including vitamins, minerals & herbs, including: pycnogenal, germanium, vitamins C & E, chondroitin, and so on. of aloe vera.

Increases the overall health & performance.

Dramatic improvement in conditions weakened.

Augmented absorption, assimilation, the use of vitamins, herbs & minerals.

The role of powerful anti - oxidant for the protection of free radical damage.

2. Analgesic - For treatment of pain & headaches.

The noni tree is also known as the "Tree of Pain & Headache".

Benefits for the back & neck pain, muscle & nerve pain, migraine & headaches from the tension.

A 1990 study conducted in the laboratory of the University of Pharmacosny Find in France found noni to have a central analgesic effect.

According to studies reported in the journal Planta Medica (and Analgesic Effects of Morinda citrifolia Behavourial; Pages 430 - 434, October 1990) noni has been found to be 75% as effective as morphine sulfate to relieve pain without the toxic effects on the side of morphine. Unlike morphine, noni is not addictive.

3. Support the immune as clinical trials conducted by Dr. Schechter, the director of the Natural Healing Institute in California,

Noni stimulates the production of T - CELL in the immune system. The T - cells play an essential role in fighting the disease.

Acts of Noni to enhance the immune system that involves macrophages and / or lymphocytes, which are an essential part of the body's natural defenses.

Noni has been shown to combat many types of bacteria.

Noni is an anticancer, inhibits the growth of cancer tumors by allowing abnormal cells to function more normally.

4. Anti - inflammatory - Cash for muscle and joints condition such as arthritis, carpal tunnel syndrome.

The reduction of pain and swelling in injuries such as bruises, burns and efforts.

Benefits for ulcers, Cellulitis, the terms of hair, biting the rashes.

Use as a poultice, applied to the affected skin.

5. Adaptogen (standardized Function)

Helps restore internal organs of the body to normal function.

Scientific documentation of benefits for the gastrointestinal (diarrhea, heartburn, nausea, colitis, ulcers) reproductive organs (menstrual problems, fibroids, yeast infections) liver & pancreas (diabetes mellitus, Pancreatitis) respiratory system (asthma, sinusitis, the emphysema) endocrine system (thyroid & adrenal disease) cardiovascular system (heart disease, high blood pressure, stroke) & nervous system (the emphasis, depression, memory, libido, energy)

The isolation of the compound called noni scopoletin by the University of Hawaii in 1993 attributes the new compound to lower the tension, reducing inflammation, killing bacteria & fungi & preventing tumor growth.

The phytonutrient, damnacanthal, found in noni, was found to be an inhibitor of some precancerous cells. The reference: "The induction of phenotypes in normal cells transformed by ras - damnacanthal of Morinda citrifolia" Hiramatsu T, et al. Letters From 75: 161 - 166 (1993) of cancer.

Antibacterial, antifungal and antiparasitic agent.

With the presence of active components wants anthraquinones, scopoletin & terpenes (eg. Beta - carotene & ursolic acid) Noni is effective against bacteria and fungus.

Extracts damnacanthal, one of the halls of anthraquinone has been shown to kill the parasite responsible for malaria called Plasmodium falciparum. Reference: The Medical Parasitology, The C. V. The Mosby Company, London (1971)

Is to Damnacanthal too powerful against leishmaniasis, a parasitic condition.

Another compound called anthraquinone of alizarin inhibits virus (HIV) human immunodeficiency. The reference: "Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase" Hirotaka H, et al. Research (1991) 15 (3) 205 - 216 antiviral.

Noni screened the action when a vigorous anti - alcoholic extract which consists of Morinda citrirolia & other plants were tested in the worm parasite called human Ascaris lumbricoides. The reference: "Research on indigenous plants for anthelmintic action against human Ascaris lumbricoides: farewell II" Pharmacol (1975) Indian J Physiol 19: Unknown.

Investigators in the Philippines reported that a concentration of noni leaves killed 89% of Mycobacterium tuberculosis, the bacteria that cause tuberculosis. The researchers identified the sites active in the noni plant to plant steroids, or phytosterols. Reference: "Potential antimycobacterial agents isolated from the leaves of noni" Saludes J, et al. The International Chemical Congress of Pacific • Basin Societies, Honolulu (2000)

About Dr. Ralph Heinicke.

Ralph Heinicke graduated from Cornell University in 1936 with a special interest in plant physiology. After completing his studies in electrical engineering at the University of Kentucky, Lexington, he went on to receive his Ph. D. in biochemistry from the University of Minnesota. He lived in Hawaii from 1950 to 1986, doing research for the Society of Pineapple Paro, for the Research Institute of Pineapple, and for the University of Hawaii.

The Origins of Xeronine - The first step in his discovery of the active ingredients of the fruit of Morinda citrifolia was at his job in the Pineapple Company of Paro. The commission was found medicinal uses for an enzyme that was predominant in the pineapple, bromelain. Dr. Heinicke published several articles in scientific journals detailing the findings of its investigation. Ever since about 1972, Dr. Heinicke had been trying to identify the unknown ingredient in bromelain, which he believed was truly responsible for the encouraging results of their clinical work. After many years of research, he eventually identified this ingredient as a new alkaloid that gave him the name "xeronine. " In December 1981, he patented xeronine as a new alkaloid.

The trail leads to Morinda citrifolia - Because he was convinced of the potential benefits as a result of their research, Dr. Heinicke set out to find a source of food that was high in the proxeronine (the precursor to xeronine) that could be used as a food supplement. Living in Hawaii, he had heard of many grievances that had been made about the M. citrifolia plant, so he chose the fruit of this plant as the subject of his search for a supplement of xeronine. He discovered that the plant not only contains huge amounts of proxeronine, the precursor to xeronine, but which also contains the proxeronase of the enzyme that facilitates the conversion of proxeronine to xeronine in the body.

Dr. Heinicke has spent most of his life in the study of M. citrifolia and the nature of their health, including xeronine and proxeronine. "I have worked directly with Morinda laboratory for further investigation that began in the health of M. citrifolia, including xeronine and its precursor, proxeronine. Morinda citrifolia M. harvest exclusively from French Polynesia, the source of the highest quality M. citrifolia with the highest levels of proxeronine of any fruit in the world. ".

Source: Heinicke, R. M. and Levand, O. of the Ferulic acid as a component of a complex carbohydrate polymer of Bromelain, of Phytochemistry Vol. 7, 1968, pp. 1659 to 1662.

Heinicke, R. M. and Gortner, W. A. The Stem Bromelain - A New Preparation of Protease of the Pineapple Plant, the Economic Botany 11, 1957, pp 225 - 234.

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How to take Noni.

When a new NONI consumer, you should drink at least 3 months to make a correct decision for what is the efficiency in your body. Every body is different. Some people have warned as a result only a few days while others do not see a change until several months later. Give him a fair chance to work.

Drink plenty of water before & after drinking noni juice to help the body absorbs the juice & couples toxins from the system. Gently shake the bottle before drinking. Mix with water or your favorite fruit juice if you want (does not reduce the effectiveness of the juice)

NONI: Juice can be taken daily as a supplement to help maintain good health.

Phase I Study of Noni in Cancer Patients.

This study is currently recruiting patients.

Sponsored by.

National Center for Complementary and Alternative Medicine (NCCAM)

Purpose.

The purpose of this Phase 1 study is to: 1. determine the maximum tolerated dose of capsules containing 500mg of freeze dried noni fruit extract, 2. define toxicities associated with the ingestion of noni, 3. collect preliminary information on the efficacy of noni in respect to anti - tumor properties and Symptom control to help select specific patients for subsequent Phase 2 studies, 4. identify chemical constituents of the extract that can be used to characterized the Bioavailability and pharmacokinetics of noni food supplement.

Condition.

Treatment or Intervention.

Phase.

Neoplasms.

Neoplasm Metastasis.

Drug: Noni Extract.

Phase I.

MedlinePlus related topics: Cancer; Alternative Cancer Therapy.

Study Type: Interventional.

Study Design: Treatment.

Further Study Details:

This Phase I study of noni in cancer patients represents a first step in the systematic study of Complementary and Alternative Medicine (CAM) practices that draw on Asian and Pacific Island cultural traditions of healing to control cancer and its related symptoms. Noni, extracted from Morinda citifolia or the Indian mulberry plant, is included in the Pharmacopoeia of traditional Native Hawaiians, other Pacific Islanders and Asian populations, and has been used to treat various diseases for hundreds of years. It is now commonly taken by cancer patients based on Purported usefulness in the disease although there is little scientific evidence to either support or refute these claims. A large marketing enterprise and at least eleven different suppliers supports the food supplement's popularity. The broad long range objectives which will initiate this study are to define the usefulness of noni extracts for cancer patients. The hypothesis to be tested is that noni at a specified dosing provides cancer patients with a sufficient benefit to toxicity profile to be useful as a therapeutic. Specific aims of this study are: 1. Determine the maximum tolerated dose of capsules containing 500mg of freeze - dried noni fruit extract. 2. Define toxicities associated with the ingestion of noni. 3. Collect preliminary information on the efficacy of noni in respect to anti - tumor properties and Symptom control to help select specific patients for subsequent Phase II studies. 4. Identify chemical constituents of the extract that can be used to characterized the Bioavailability and pharmacokinetics of noni food supplement.

Eligibility.

Genders Eligible for Study: Both.

Criteria.

Patients must:

Have a cytologically or pathologically verified diagnosis of cancer and evidence of disease for which no standard treatment is available;

Be ambulatory, capable of self care, and up and about more than 50% of Waking hours;

Have completed all other cancer treatments at least four weeks previously;

On any Medications have been considered by their physician to be essential to their health (eg lipid lowering, antidiabetic, antihypertensive) at consistent dosing at least four weeks prior to starting noni;

Agree to take no other CAM treatments while taking noni and agree to keep a diary, recording all Medications taken daily, including all non - prescription products and to record the time that noni is taken.

Location and Contact Information.

Faith Inoshita, RN, MS 808 - 586 - 2979 faithi@crch. hawaii. edu.

Hawaii.

University of Hawaii Cancer Research Center, Honolulu, Hawaii, 96813, United States; Recruiting.

Study chairs or principal investigators.

Brian F. Issell, MD, FRACP, Principal Investigator, University of Hawaii.

More Information.

Study ID Numbers 1 R21 AT00896 - 01.

Study Start Date November 2001; Estimated Completion Date June 2003.

Record last reviewed April 2004.

NLM Identifier NCT00033878.

ClinicalTrials. gov processed this record on 2004 - 05 - 12.

U. S. National Library of Medicine, NLM Contact Customer Service.

National Institutes of Health, Department of Health & Human Services.

Copyright, Privacy, Accessibility, Freedom of Information Act.

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